Covishield vaccine produced extra antibodies than Covaxin, in response to a preliminary examine by Coronavirus Vaccine-induced Antibody Titre (COVAT) involving healthcare staff (HCW) who’ve obtained each doses of both of the 2 vaccines.
Seropositivity charges to anti-spike antibody have been considerably greater in Covishield recipients in comparison with Covaxin after the primary dose, the examine claimed.
The examine is a preprint and has not been peer-reviewed, so shouldn’t be used to information scientific apply.
It stated that each vaccines– Covishield and Covaxin– elicited an excellent response after two doses, however seropositivity fee and median anti-spike antibody have been considerably greater in Covishield.
“Amongst the 552 HCW (325 Male, 227 Feminine), 456 and 96 obtained the primary dose of Covishield and Covaxin respectively. General, 79.3 per cent confirmed seropositivity after the primary dose. Responder fee and median (IQR) rise in anti-spike antibody have been considerably greater in Covishield vs. Covaxin recipient (86.8 vs. 43.8 per cent; 61.5 vs. 6 AU/ml; each p<0.001),” the examine stated.
The examine concerned these healthcare staff who’ve been administered both of the 2 vaccines Covishield and Covaxin and are with or with out previous historical past of SARS-CoV-2 an infection.
“This ongoing, Pan-India, Cross-sectional, Coronavirus Vaccine-induced Antibody Titre (COVAT) examine is being performed amongst HCW, with or with out previous historical past of SARS-CoV-2 an infection. SARS-CoV-2 anti-spike binding antibody is being assessed quantitatively at 4 timepoints between 21 days or extra after the primary dose to six months after the second dose,” the examine stated.
Nevertheless, the conclusion of the examine stated that each the vaccines have proven elicited good immune response.
“Whereas each vaccines elicited immune response, seropositivity charges to anti-spike antibody have been considerably greater in Covishield recipient in comparison with Covaxin after the primary dose. Ongoing COVAT examine will additional enlighten the immune response between two vaccines after the second dose,” it stated.
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